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珀金埃爾默醫(yī)學(xué)診斷產(chǎn)品（上海）有限公司


當(dāng)前位置：珀金埃爾默醫(yī)學(xué)診斷產(chǎn)品（上海）有限公司>>>>IP-10 (human, recombinant), [125I]-, Bolton-Hunter Labeled, 5µCi

IP-10 (human, recombinant), [125I]-, Bolton-Hunter Labeled, 5µCi

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Interferon gamma-induced protein 10 (IP-10; CXCL10), labeled with 125I. IP-10 binds the chemokine CXCR3 receptor, and is secreted in response to IFN-γ.

詳細(xì)介紹

We offer radioligands and radiolabeled biomolecules to use as tracers, for radioimmunoassays (RIAs), for autoradiographic visualization, or for performing saturation and competition radioligａnd binding assays to determine receptor expression levels (Bmax), dissociation constants (Kd), association and dissociation rates (kon and koff), and inhibitor constants (Ki) for a variety of receptors. We develop our radioligands to the highest specific activity possible and provide high purity resulting in low non-specific binding products. Each of our ultra-pure radiolabeled compounds is fully characterized for pharmacological action and validated in binding assays.

Radiochemicals remain the most sensitive method for probing binding biology; yielding unprecedented sensitivity gives results that technicians and scientists can trust. For over 50 years, PerkinElmer has been a leading supplier of New Englａnd Nuclear (NEN) radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments.

References for NEX348:

  1. Gao, J.M., Xiang, R.L., Jiang, L., Li, W.H., Feng, Q.P., Guo, Z.J., Sun, Q., Zeng, Z.P., Fang, F.D. (2009), Sulfated tyrosines 27 and 29 in the N-terminus of human CXCR3 participate in binding native IP-10. Acta Pharmacol Sin., 30 (2): 193-201.
  2. Jenh, C.H., Cox, M.A., Hipkin, W., Lu, T., Pugliese-Sivo, C., Gonsiorek, W., Chou, C.C., Narula, S.K., Zavodny, P.J. (2001), Human B cell-attracting chemokine 1 (BCA-1; CXCL13) is an agonist for the human CXCR3 receptor. Cytokine, 15 (3): 113-121.

規(guī)格

濃度 41.4 µCi/mL
檢測(cè)方法 Radiometric
新鮮的很多天 Third Monday of each month
標(biāo)簽位置 Nominally Labeled
產(chǎn)品品牌名稱 NEN Radiolabeled Ligands
放射性同位素 I-125
放射性核素 125I
受體類型 Chemokine
運(yùn)輸條件 干冰
特殊訂購(gòu)信息 This is a radioactive product - shipping address must have a license to receive radioactive materials.
治療領(lǐng)域 Inflammation
產(chǎn)品尺寸 5 µCi

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